Biological Signal Intelligence · Folio I

The biological signature of mental health.

One reusable engine that turns non-invasive biology into a stratified, auditable signal, proven first on burnout.

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Literature-grounded Auditable by design Non-diagnostic

Privacy by architecture

Your biology never leaves your control.

Pseudonymised at source, encrypted end to end.

Pseudonymised at source

Identity is split from biology before a sample is scored.

ISO 13485 quality framework

Developed under the medical-device quality-management standard for diagnostic software.

GDPR & health-data compliant

Built to EU health-data standards, audit trail on every result.

“

We need to bring the same rigor to mental disorders that we use elsewhere in medicine: measurable, biological signals instead of relying solely on what people report.

Thomas Insel, M.D., former Director, U.S. National Institute of Mental Health

The NeuraScore^™ engine

A single validated core. A growing library of modules.

One non-invasive sample in; a stratified, auditable signal out. The same engine reads condition after condition.

More details →

Signal pathper sample

Sample

Quality

Engine

Score

Stratified NeuraScoreconfidence

Field figures

A market shaped by unmet measurement.

15%

Belgian workers reporting emotional exhaustion.

SPF Emploi · 2021

^€2B+

Annual cost of burnout & depression absences in Belgium.

INAMI · 2023

^€1.5B+

Addressable European market for stress & burnout testing.

Grand View Research · 2024

The gap we close

Symptom checklists where there should be signal.

Standard of care

Clinical judgment, alone.

i.Diagnosis by symptom checklist (MBI / BAT)
ii.Self-reported, prone to bias and late detection
iii.No biological basis to separate overlapping conditions

The NeuraSens method

Evidence, measured.

i.Non-invasive multi-axis biological panel
ii.Stratified score, confidence tier and action route
iii.Every line traceable to a peer-reviewed source

Built with the Walloon research ecosystem

Win4Company

CHU Liège

UCLouvain

DNAlytics

Quality Assistance

The NeuraScore^™ platform

A revolutionary data signal-processing architecture in biology.

One deterministic, auditable engine turns non-invasive biology into a stratified signal, reused condition after condition.

Signal path

inputs → gating → convergence → output

Inputs

A single non-invasive sample and a controlled questionnaire enter together.

Non-invasive biology

multiple independent axes, one sample

Structured context

a questionnaire that cleans interpretation

Quality & gating

Preanalytic QC and explicit gates set what each sample is allowed to claim. Known confounds are handled before anything is scored.

QC checks Hard gates Confounds

03Core

Convergence engine

Independent signals must agree. The engine weighs the convergence of patterns, never a sum of markers.

Stratified output

NeuraScore

Confidence tier

Pattern & subtype

Action & retest

Confidence

Golden thread · auditable end to end

every result traces from intake to export

OrderSampleRuleEvidenceAudit

Foundation

SOP & sample stability

Pseudonymised & governed

Modular platform scale-out

Why it holds up

[ I ]

Fully auditable.

Every result traces back to its graded evidence and stays reviewable end to end, never a black box.

[ II ]

Governed by design.

The runtime is deterministic. Rules stay frozen and versioned; nothing is improvised per sample.

[ III ]

Reusable core.

Each module adds a rule pack; the engine core is unchanged, decreasing cost per condition.

In plain terms

Explicit gateA hard rule that decides what a sample is allowed to claim before it is scored.ConfoundsOutside factors, such as illness, medication or timing, that can distort a biological signal.Modular scale-outAdding new conditions as separate rule packs on the same core engine.Graded evidenceFindings weighted by how strong the supporting research is.Deterministic runtimeThe same inputs always produce the same result, with no randomness.Frozen & versioned rulesScoring rules are locked and version-tracked, never changed per sample.

Beyond one sample, beyond one disease

Matrix-agnostic. Condition-agnostic.

The core does not care which sample it reads or which condition it is asked about. It scores the biology it is given, stratifies risk into tiers, and reroutes each person to the right next step when one is needed.

Any non-invasive matrix

UrineSalivaDried bloodPlasma

Whatever a clinic or study can realistically collect, the engine reads.

Any condition

BurnoutOvertrainingADHDPTSDAddictionAlzheimer's

Each a rule pack on the same core. The stratification logic never changes.

Stratify & routeper person

Low signal loadMonitor & retest

ModerateGuided support

ElevatedClinical referral

Masked / unclearFlag for human review

A stratification and triage layer that decides where a person goes next.

The module library · six modules, one engine

Live

NeuraScore^™: Burnout

Occupational burnout

The flagship module: biological stratification of work strain, with masked-burnout detection.

Roadmap

NeuraScore^™: Overtraining

Overtraining syndrome

Recovery-first routing for athletes and high-load populations.

Roadmap

NeuraScore^™: ADHD

Attention regulation

Objective profiling to complement subjective screening tools.

Roadmap

NeuraScore^™: PTSD

Trauma burden

Directionality of the stress response as the differentiating signal.

Roadmap

NeuraScore^™: Addiction

Substance use

Reward-axis biology mapped onto the same convergence logic.

Roadmap

NeuraScore^™: Alzheimer's

Neurodegeneration

Proof the engine is matrix-agnostic, beyond urine, into plasma.

Scientific basis

Reading mental health as biology, not category.

Burnout, low mood and anxiety overlap on a continuous spectrum. We read that spectrum through biological domains, not discrete boxes.

A shared spectrum

Conditions are regions on one biological continuum, not separate boxes.

Anxiety Burnout Depression PTSD

The same biological systems recur across burnout, depression, anxiety and trauma with different signatures. NeuraScore reads where on the continuum a person sits, not which box they belong to.

The body is a metabolic system before it is a psychiatric category: we read the system, not the label.

NeuraCorp founding principle

In plain terms

NeuraSens reads mental health from the body’s biology rather than from questionnaires alone. From a single non-invasive sample we measure a panel of biological signals and turn them into a clear, stratified score. The rest of this page explains the two scientific lenses we use to read those signals, and why one biology can speak to several conditions.

Mental-health conditions rarely map to a single marker. The same biological signals regroup depending on the scientific lens you read them through.

Interactive · switch the lens

Two lenses, one set of signals.

The same biological signals

RDoC domains

RDoC · Research Domain Criteria

The US National Institute of Mental Health framework replaces diagnostic labels with measurable functional domains: arousal and regulatory systems, negative and positive valence, cognition and social processes. A person is described by where they sit on each domain, read from biology, rather than by the category they were assigned.

Arousal & RegulatoryHow the body ramps up and settles down: the stress (HPA) axis and the sleep-wake balance.Negative ValenceSystems for threat, fear and loss that drive low mood and anxiety.Cognitive SystemsAttention, memory and mental control.

Metabolic psychiatry

A fast-growing field that treats many psychiatric conditions as, in part, disorders of energy metabolism, inflammation and circadian regulation. It looks for the mechanism beneath the symptom: mitochondrial function, HPA-axis load and immune signalling, and reads mental health as a systemic, measurable state.

Energy metabolismHow cells produce and use energy, including mitochondrial function.InflammationLow-grade immune activation that can affect the brain.Circadian regulationThe body’s daily clock governing sleep, hormones and rhythm.Oxidative stressCellular wear from an imbalance of reactive molecules.

Validation

The rule base is built from a graded, DOI-traceable literature corpus. The first module is validated on a cohort of Walloon workers against established burnout inventories, with explicit detection of masked burnout, where biology and self-report diverge.

The company

A focused team across science, data & strategy.

A core team, specialist consultants and Walloon subcontractors, coordinated end to end.

Ameur Dhouieb

Founder / CEO

Designed the NeuraScore architecture and leads platform strategy and B2B pilots.

Core competences

NeuraScore architectureSignal-processing designPrecision-health strategy

MA · Science, Technology & Innovation, HSE University LinkedIn

Emma Biggs

Health Psychology Lead

Designs the structured-context instrument that guards interpretation against behavioural confounds.

Core competences

Health psychologyCognitive neuroscienceReal-world dataNeuroimaging

PhD · Psychology, KU Leuven & Maastricht

Claudio Reggiani

Data Engineering & ML

Builds the data pipeline and calibration models behind each module.

Core competences

Data engineeringMachine learningCloud / AWSGenomics pipelines

PhD · Computer Science, ULB

Katty Prentice

COO

Runs CRO coordination, regulatory strategy (IVDR/CE) and day-to-day operations.

Core competences

Project managementRegulatory affairsCRO coordinationScientific writing

PhD · Biosystems Engineering, Ghent University

Thierry Ferain

Chief Innovation Officer

Connects NeuraSens to the Walloon research, development and innovation ecosystem.

Core competences

Innovation strategyTranslational researchPublic-private partnershipsR&D portfolio

PhD · Molecular Genetics, UCLouvain

François Blistein

Signal Processing & AI Engineer

Builds real-time signal-processing and edge-AI pipelines, from radar, LiDAR and medical imaging to production ML.

Core competences

Signal processingMachine learningEdge AIMedical imaging

MSc · Electrical Engineering, University of Liège

Contact

Want to talk to the team?

Employer, occupational-health team, clinician, partner or investor: request a briefing and we'll set up a conversation.

Request a Briefing Read the science →

Contact

Request a briefing.

For employers, occupational-health teams, clinicians and partners. NeuraCorp SRL, Brussels.

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Write to us directly and we'll route your request to the right person.

hello@neurasens.be

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